GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Esr1 | decreases methylation | EXP | | 6480464 | CTD | Arsenic results in decreased methylation of ESR1 promoter | PMID:15026472 | Esr1 | increases expression | EXP | | 6480464 | CTD | Arsenic results in increased expression of ESR1 mRNA; Arsenic results in increased expression of ESR1 protein | PMID:15026472 PMID:19450653 | Esr1 | decreases expression | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Arsenic results in decreased expression of ESR1 mRNA; Arsenic results in decreased expression of ESR1 protein | PMID:33047385 | Esr1 | increases expression | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Arsenic results in increased expression of ESR1 mRNA | PMID:17306315 | Esr1 | multiple interactions | ISO | Esr1 (Rattus norvegicus) | 6480464 | CTD | 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of ESR1 protein]; [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of ESR1 mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of ESR1 protein; Acetylcysteine inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of ESR1 protein]; IL1RN protein inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of ESR1 protein]; Succimer inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of ESR1 protein] | PMID:32402895 PMID:35993674 | Esr1 | multiple interactions | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | [Estradiol co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased expression of ESR1 mRNA | PMID:35747940 | | ||||||||||||||||||||||
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