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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:44658
Term: okadaic acid
Definition: A polycyclic ether that is produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and shellfish. A polyketide, polyether derivative of a C38 fatty acid, it is one of the primary causes of diarrhetic shellfish poisoning (DSP). It is a potent inhibitor of specific protein phosphatases and is known to have a variety of negative effects on cells.
Chemical ID: MESH:D019319
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1decreases expressionISOESR1 (Homo sapiens)6480464CTDOkadaic Acid results in decreased expression of ESR1 proteinPMID:15965230
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Okadaic Acid results in increased degradation of ESR1 mRNA]; Okadaic Acid inhibits the reaction [Linoleic Acids, Conjugated results in decreased phosphorylation of ESR1 protein]; Okadaic Acid results in increased degradation of and results in decreased expression of ESR1 mRNAPMID:15965230 PMID:19800873
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