GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Esr1 | multiple interactions | EXP | | 6480464 | CTD | [[INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] co-treated with Diethylstilbestrol] results in decreased activity of ESR1 protein; [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ESR1 mRNA | PMID:26944108 PMID:28849599 | Esr1 | decreases expression | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | Dexamethasone results in decreased expression of ESR1 mRNA | PMID:16691199 PMID:19022236 | Esr1 | multiple interactions | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | [Estradiol co-treated with Dexamethasone] results in decreased expression of ESR1 mRNA; [Estradiol co-treated with Dexamethasone] results in decreased expression of ESR1 protein; ESR1 mutant form inhibits the reaction [Estradiol inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 mRNA]]; ESR1 mutant form inhibits the reaction [Genistein inhibits the reaction [Dexamethasone results in increased expression of LEFTY1 mRNA]]; ESR1 mutant form inhibits the reaction [Genistein inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 mRNA]]; ESR1 mutant form promotes the reaction [Dexamethasone results in increased expression of TSC22D3 mRNA] | PMID:23183181 PMID:25136773 | |
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