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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:28179
Term: benzamide
Definition: An aromatic amide that consists of benzene bearing a single carboxamido substituent. The parent of the class of benzamides.
Chemical ID: MESH:C037689
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDbenzamide analog inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to CTSD promoter]]; benzamide analog inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to MYC promoter]]; benzamide analog inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to NCOA3 protein]]; benzamide analog inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to TFF1 promoter]]; benzamide analog inhibits the reaction [Estradiol results in increased phosphorylation of and results in increased localization of ESR1 protein]; benzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to CTSD promoter]]; benzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to MYC promoter]]; benzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to NCOA3 protein]]; benzamide analog inhibits the reaction [Tamoxifen promotes the reaction [ESR1 protein binds to TFF1 promoter]]; benzamide analog inhibits the reaction [Tamoxifen results in increased phosphorylation of and results in increased localization of ESR1 protein]PMID:17157789
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