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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:17263
Term: estrone
Definition: A 17-oxo steroid that is estra-1,3,5(10)-triene substituted by an hydroxy group at position 3 and an oxo group at position 17.
Chemical ID: MESH:D004970
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1affects bindingEXP 6480464CTDEstrone binds to ESR1 proteinPMID:11162928 PMID:19913605
Esr1affects bindingISOESR1 (Homo sapiens)6480464CTDEstrone binds to ESR1 proteinPMID:11162928 PMID:11518614 PMID:12598185 PMID:19233257 PMID:19913605
Esr1increases activityISOEsr1 (Rattus norvegicus)6480464CTDEstrone results in increased activity of ESR1 proteinPMID:11750080
Esr1increases activityISOESR1 (Homo sapiens)6480464CTDEstrone results in increased activity of ESR1 proteinPMID:11331656 PMID:22562034
Esr1increases expressionISOESR1 (Homo sapiens)6480464CTDEstrone results in increased expression of ESR1 mRNAPMID:29783106
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDEstrone binds to and results in increased activity of ESR1 protein; Estrone inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; Estrone inhibits the reaction [ESR1 results in increased susceptibility to Cisplatin]; Estrone inhibits the reaction [Estradiol binds to ESR1 protein]; Estrone promotes the reaction [ESR1 protein alternative form binds to ESR1 protein alternative form]; Estrone promotes the reaction [ESR1 protein binds to ESR1 protein]; Estrone promotes the reaction [ESR1 protein modified form binds to NCOA1 protein modified form]; Estrone promotes the reaction [ESR1 protein modified form binds to NRIP1 protein modified form]; Fulvestrant inhibits the reaction [Estrone results in increased activity of ESR1 protein]PMID:12127041 PMID:12676605 PMID:18026938 PMID:19233257 PMID:21767602 PMID:22562034 PMID:23383871 PMID:25012808 PMID:26865669 PMID:29162470 PMID:33049310 PMID:9048584
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