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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:16598
Term: DDE
Definition: A chlorophenylethylene that is ethylene substituted by two 4-chlorophenyl groups at position 1 and two chlorine atoms at position 2.
Chemical ID: MESH:D003633
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1multiple interactionsEXP 6480464CTD[Dichlorodiphenyl Dichloroethylene co-treated with beta-hexachlorocyclohexane] results in increased expression of ESR1 mRNAPMID:16758953
Esr1affects bindingISOESR1 (Homo sapiens)6480464CTDDichlorodiphenyl Dichloroethylene binds to ESR1 protein; Dichlorodiphenyl Dichloroethylene metabolite binds to ESR1 proteinPMID:10492897 PMID:14579009 PMID:19913605 PMID:32278787
Esr1decreases expressionISOESR1 (Homo sapiens)6480464CTDDichlorodiphenyl Dichloroethylene results in decreased expression of ESR1 mRNAPMID:20206645
Esr1increases activityISOEsr1 (Rattus norvegicus)6480464CTDDichlorodiphenyl Dichloroethylene results in increased activity of ESR1 proteinPMID:17174995 PMID:9860891
Esr1increases activityISOESR1 (Homo sapiens)6480464CTDDichlorodiphenyl Dichloroethylene analog results in increased activity of ESR1 protein; Dichlorodiphenyl Dichloroethylene results in increased activity of ESR1 proteinPMID:15064155 PMID:18801367 PMID:26022396
Esr1increases expressionISOESR1 (Homo sapiens)6480464CTDDichlorodiphenyl Dichloroethylene results in increased expression of ESR1 mRNAPMID:21295777
Esr1multiple interactionsISOEsr1 (Rattus norvegicus)6480464CTD[o,p'-DDT co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Methoxychlor co-treated with Endosulfan co-treated with DDT] results in increased activity of ESR1 protein; [Plasticizers co-treated with Fungicides, Industrial co-treated with Linuron co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with Dichlorodiphenyl Dichloroethylene co-treated with butylparaben co-treated with Acetaminophen] results in decreased expression of ESR1 mRNAPMID:34383603 PMID:9860891
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDDichlorodiphenyl Dichloroethylene binds to and results in increased activity of ESR1 protein; Dichlorodiphenyl Dichloroethylene inhibits the reaction [[Dihydrotestosterone co-treated with Estradiol] results in decreased expression of ESR1 protein]; Dichlorodiphenyl Dichloroethylene inhibits the reaction [Estradiol binds to ESR1 protein]; Fulvestrant inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in decreased expression of ESR1 mRNA]PMID:14579009 PMID:18275596 PMID:20206645 PMID:29162470 PMID:33049310
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