GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Esr1 | affects response to substance | EXP | | 6480464 | CTD | ESR1 protein affects the susceptibility to 27-hydroxycholesterol | PMID:17873880 | Esr1 | multiple interactions | EXP | | 6480464 | CTD | ESR1 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS2 mRNA]; ESR1 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS3 mRNA] | PMID:17873880 | Esr1 | increases degradation | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | 27-hydroxycholesterol results in increased degradation of ESR1 protein | PMID:17872378 | Esr1 | multiple interactions | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | 27-hydroxycholesterol binds to and affects the folding of and results in increased activity of ESR1 protein; 27-hydroxycholesterol binds to and results in decreased activity of ESR1 protein; 27-hydroxycholesterol inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein]; 27-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; 27-hydroxycholesterol promotes the reaction [ESR1 protein binds to TFF1 promoter]; Fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased activity of ESR1 protein] | PMID:17872378 PMID:17873880 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |