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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:38626
Term: pyridaben
Definition: An organochlorine acaricide that has formula C19H25ClN2OS.
Chemical ID: MESH:C428725
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1increases activityISOESR1 (Homo sapiens)6480464CTDpyridaben results in increased activity of ESR1 proteinPMID:20143881
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDpyridaben binds to and results in increased activity of ESR1 protein; pyridaben inhibits the reaction [Estradiol results in increased activity of ESR1 protein]PMID:30818834 PMID:33049310
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