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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:34857
Term: Moxestrol
Definition: A 3-hydroxy steroid that has formula C21H26O3.
Chemical ID: MESH:C011310
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1increases activityISOESR1 (Homo sapiens)6480464CTDmoxestrol results in increased activity of ESR1 proteinPMID:10875235
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDmoxestrol inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; moxestrol promotes the reaction [ESR1 protein binds to SERPINB9 protein]; moxestrol promotes the reaction [ESR1 protein binds to TFF1 protein]PMID:14617632 PMID:9048584
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