A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID:
MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
[Dietary Sucrose co-treated with Dietary Fats co-treated with bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] affects the expression of ESR1 mRNA; [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ESR1 protein; [Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A co-treated with Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of ESR1 mRNA; [Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of ESR1 mRNA; [Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with Dietary Fats] results in increased expression of ESR1 mRNA; [Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] inhibits the reaction [Dietary Fats results in increased expression of ESR1 mRNA]; [Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] inhibits the reaction [Dietary Fats results in increased expression of ESR1 protein]; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ESR1 mRNA
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ESR1 protein]; [Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [ESR1 protein binds to CYP1A1 enhancer]; [Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [ESR1 protein binds to GREB1 promoter]; [Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [ESR1 protein binds to TFF1 promoter]; [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of and results in increased degradation of ESR1 protein; [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased ubiquitination of ESR1 protein; [Tetrachlorodibenzodioxin co-treated with Estradiol] promotes the reaction [ESR1 protein binds to CYP1A1 enhancer]; [Tetrachlorodibenzodioxin co-treated with Estradiol] promotes the reaction [ESR1 protein binds to CYP1A1 promoter]; [Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in increased activity of ESR1 protein; afimoxifene inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 promoter]]; afimoxifene inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 promoter]]; AHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Estradiol results in decreased expression of ESR1 protein]]; AHR gene mutant form promotes the reaction [[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [ESR1 protein binds to TFF1 promoter]]; AHR protein promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CCNG2 gene]]; AHR protein promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 gene]]; AHR protein promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to ITPR1 gene]]; ARNT gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Estradiol results in decreased expression of ESR1 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ESR1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of ESR1 protein]; ESR1 protein inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1B1 gene]]; ESR1 protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CCNG2 mRNA]; ESR1 protein promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GREB1 gene]]; ESR1 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; ESR1 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]; Estradiol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CAD promoter]]; Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 promoter]]; Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 promoter]]; FOXA1 protein affects the reaction [Tetrachlorodibenzodioxin inhibits the reaction [[Estradiol binds to ESR1 protein] which results in decreased expression of CCNG2 mRNA]]; Fulvestrant inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 promoter]]; Fulvestrant inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 promoter]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 enhancer]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 enhancer]]; Metformin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to POU5F1 promoter]]; Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 enhancer]]; Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 enhancer]]; Tetrachlorodibenzodioxin inhibits the reaction [[Estradiol binds to ESR1 protein] which results in decreased expression of CCNG2 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [ESR1 protein binds to ESR2 promoter]; Tetrachlorodibenzodioxin inhibits the reaction [Estradiol binds to ESR1 protein]; Tetrachlorodibenzodioxin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to SP1 protein]]; Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in decreased expression of ESR1 protein]; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ESR1 gene]; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ESR1 protein]; Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CA12 gene]; Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CAD promoter]; Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CCNG2 gene]; Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 enhancer]; Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 gene]; Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1A1 promoter]; Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 enhancer]; Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 gene]; Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to CYP1B1 promoter]; Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to ESR1 gene]; Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to GREB1 gene]; Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to HSPB8 promoter]; Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to JAK1 gene]; Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to POU5F1 promoter]; Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to RERG gene]; Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to SYT12 gene]; Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to TBL1XR1 gene]; Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to TFF1 promoter]; Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to TIPARP 3' UTR]; Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to TSKU promoter]; Tetrachlorodibenzodioxin promotes the reaction [Estradiol promotes the reaction [ESR1 protein binds to CYP1B1 promoter]]; Tetrachlorodibenzodioxin promotes the reaction [Estradiol results in decreased expression of ESR1 protein]; Tetrachlorodibenzodioxin promotes the reaction [Estradiol results in increased degradation of ESR1 protein]; Tetrachlorodibenzodioxin results in increased degradation of and results in decreased expression of ESR1 protein
