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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1decreases expressionEXP 6480464CTDAflatoxin B1 results in decreased expression of ESR1 mRNA; Aflatoxin B1 results in decreased expression of ESR1 proteinPMID:19770486 PMID:29274131
Esr1decreases expressionISOESR1 (Homo sapiens)6480464CTDAflatoxin B1 results in decreased expression of ESR1 mRNAPMID:28965971
Esr1increases methylationISOESR1 (Homo sapiens)6480464CTDAflatoxin B1 results in increased methylation of ESR1 intronPMID:30157460
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