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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10533
Species: Mus musculus
RGD Object: Gene
Symbol: Erbb2
Name: erb-b2 receptor tyrosine kinase 2
Acc ID: CHEBI:27641
Term: cycloheximide
Definition: A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.
Chemical ID: MESH:D003513
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Erbb2decreases expressionISOERBB2 (Homo sapiens)6480464CTDCycloheximide results in decreased expression of ERBB2 mRNA; Cycloheximide results in decreased expression of ERBB2 proteinPMID:15072547 PMID:15228094 PMID:20379846
Erbb2increases degradationISOERBB2 (Homo sapiens)6480464CTDCycloheximide results in increased degradation of ERBB2 proteinPMID:25866362
Erbb2multiple interactionsISOERBB2 (Homo sapiens)6480464CTD[Cycloheximide co-treated with Estradiol] results in decreased expression of ERBB2 mRNA; Curcumin analog promotes the reaction [Cycloheximide results in increased degradation of ERBB2 protein]; PA2G4 protein promotes the reaction [Cycloheximide results in decreased expression of ERBB2 protein]PMID:15072547 PMID:20379846 PMID:25866362
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