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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10531
Species: Mus musculus
RGD Object: Gene
Symbol: Epo
Name: erythropoietin
Acc ID: CHEBI:4356
Term: desferrioxamine B
Definition: An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Chemical ID: MESH:D003676
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Epoincreases expressionEXP 6480464CTDDeferoxamine deficiency results in increased expression of EPO mRNA; Deferoxamine results in increased expression of EPO mRNAPMID:10756076
Epoincreases stabilityEXP 6480464CTDDeferoxamine deficiency results in increased stability of EPO mRNAPMID:10756076
Epoincreases expressionISOEpo (Rattus norvegicus)6480464CTDDeferoxamine results in increased expression of EPO mRNA; Deferoxamine results in increased expression of EPO proteinPMID:10559391 PMID:21558026 PMID:9927288
Epoincreases expressionISOEPO (Homo sapiens)6480464CTDDeferoxamine results in increased expression of EPO mRNAPMID:10699462
Epomultiple interactionsISOEpo (Rattus norvegicus)6480464CTDDeferoxamine inhibits the reaction [Reactive Oxygen Species results in decreased expression of EPO protein]PMID:9927288
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