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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10529
Species: Mus musculus
RGD Object: Gene
Symbol: Ephx1
Name: epoxide hydrolase 1, microsomal
Acc ID: CHEBI:6809
Term: methamphetamine
Definition: A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.
Chemical ID: MESH:D008694
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ephx1increases expressionEXP 6480464CTDMethamphetamine results in increased expression of EPHX1 mRNA; Methamphetamine results in increased expression of EPHX1 proteinPMID:26307267 PMID:31422080
Ephx1increases methylationEXP 6480464CTDMethamphetamine results in increased methylation of EPHX1 promoterPMID:26307267
Ephx1multiple interactionsEXP 6480464CTDEPHX1 protein affects the reaction [Methamphetamine results in decreased expression of BCL2 protein]; EPHX1 protein affects the reaction [Methamphetamine results in decreased expression of BCL2L1 protein]; EPHX1 protein affects the reaction [Methamphetamine results in decreased expression of TH protein]; EPHX1 protein affects the reaction [Methamphetamine results in increased expression of BAX protein]; Methamphetamine promotes the reaction [PRKCD protein modified form binds to EPHX1 protein]; PRKCD protein affects the reaction [Methamphetamine results in increased expression of EPHX1 protein]PMID:31422080
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