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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10529
Species: Mus musculus
RGD Object: Gene
Symbol: Ephx1
Name: epoxide hydrolase 1, microsomal
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ephx1affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of EPHX1 mRNAPMID:20702594 PMID:21570461
Ephx1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of EPHX1 mRNAPMID:33956508
Ephx1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of EPHX1 mRNA; Tetrachlorodibenzodioxin results in increased expression of EPHX1 proteinPMID:15328365 PMID:15800033 PMID:16611356 PMID:16960034 PMID:18163543 PMID:2208584 PMID:23994337
Ephx1multiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of EPHX1 mRNA; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of EPHX1 mRNA; Tetrachlorodibenzodioxin inhibits the reaction [NFE2L2 gene mutant form results in decreased expression of EPHX1 mRNA]PMID:17942748 PMID:21846477 PMID:28433925
Ephx1increases expressionISOEphx1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of EPHX1 mRNAPMID:16960034 PMID:32387183 PMID:33387578 PMID:34747641
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