Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	10511
Species:	Mus musculus
RGD Object:	Gene
Symbol:	Egfr
Name:	epidermal growth factor receptor

Acc ID:	CHEBI:5692
Term:	hexachlorobenzene
Definition:	A member of the class of chlorobenzenes that is benzene in which all of the hydrogens are replaced by chlorines. An agricultural fungicide introduced in the mid-1940s and formerly used as a seed treatment, its use has been banned since 1984 under the Stockholm Convention on Persistent Organic Pollutants.
Chemical ID:	MESH:D006581

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Egfr	increases expression	EXP		6480464	CTD	Hexachlorobenzene results in increased expression of EGFR mRNA	PMID:28923513
Egfr	multiple interactions	EXP		6480464	CTD	Hexachlorobenzene affects the reaction [AHR protein affects the expression of EGFR mRNA]	PMID:28923513
Egfr	increases phosphorylation	ISO	Egfr (Rattus norvegicus)	6480464	CTD	Hexachlorobenzene results in increased phosphorylation of EGFR protein	PMID:18295415
Egfr	increases phosphorylation	ISO	EGFR (Homo sapiens)	6480464	CTD	Hexachlorobenzene results in increased phosphorylation of EGFR protein	PMID:21205633
Egfr	multiple interactions	ISO	Egfr (Rattus norvegicus)	6480464	CTD	AG 1879 inhibits the reaction [SRC protein promotes the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein]]; Hexachlorobenzene promotes the reaction [EGFR protein binds to SRC protein]; Hexachlorobenzene promotes the reaction [Methylnitrosourea promotes the reaction [EGFR protein binds to SRC protein]]; Hexachlorobenzene promotes the reaction [Methylnitrosourea results in increased phosphorylation of EGFR protein]; Hexachlorobenzene results in increased phosphorylation of and results in decreased expression of EGFR protein; Methylnitrosourea promotes the reaction [Hexachlorobenzene promotes the reaction [EGFR protein binds to SRC protein]]; Methylnitrosourea promotes the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein]; SRC protein promotes the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein]	PMID:18295415 PMID:22245120
Egfr	multiple interactions	ISO	EGFR (Homo sapiens)	6480464	CTD	[AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of EGFR protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]; [RTKI cpd results in decreased activity of EGFR protein] which results in decreased susceptibility to Hexachlorobenzene; Hexachlorobenzene results in increased phosphorylation of and results in increased expression of EGFR protein	PMID:21205633 PMID:23462309

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