GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Egfr | decreases expression | EXP | | 6480464 | CTD | Arsenic Trioxide results in decreased expression of EGFR protein | PMID:23029451 | Egfr | multiple interactions | EXP | | 6480464 | CTD | [Arsenic Trioxide co-treated with huachansu] results in decreased expression of EGFR protein | PMID:21434348 | Egfr | affects response to substance | ISO | EGFR (Homo sapiens) | 6480464 | CTD | EGFR protein affects the susceptibility to Arsenic Trioxide; EGFR protein mutant form affects the susceptibility to Arsenic Trioxide | PMID:29535630 PMID:30237564 | Egfr | decreases expression | ISO | EGFR (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in decreased expression of EGFR mRNA; Arsenic Trioxide results in decreased expression of EGFR protein | PMID:20435036 PMID:23029451 PMID:30237564 | Egfr | increases expression | ISO | EGFR (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in increased expression of EGFR mRNA | PMID:22521957 PMID:29274334 | Egfr | increases phosphorylation | ISO | EGFR (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in increased phosphorylation of EGFR protein | PMID:22532027 | Egfr | multiple interactions | ISO | EGFR (Homo sapiens) | 6480464 | CTD | 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of EGFR protein]; [Arsenic Trioxide co-treated with Pamidronate] promotes the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Arsenic Trioxide promotes the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Arsenic Trioxide promotes the reaction [EGFR protein mutant form binds to SQSTM1 protein]; Arsenic Trioxide results in decreased expression of and results in decreased phosphorylation of EGFR protein; Arsenic Trioxide results in increased phosphorylation of and results in increased activity of EGFR protein; bafilomycin A1 inhibits the reaction [Arsenic Trioxide results in decreased expression of EGFR protein]; Cycloheximide promotes the reaction [Arsenic Trioxide results in decreased expression of EGFR protein]; Erlotinib Hydrochloride inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of EGFR protein]; NCF2 mutant form inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of EGFR protein]; SQSTM1 protein affects the reaction [Arsenic Trioxide results in decreased expression of EGFR protein]; SQSTM1 protein inhibits the reaction [Arsenic Trioxide results in decreased expression of EGFR protein] | PMID:15961274 PMID:22532027 PMID:23548265 PMID:30237564 PMID:32337366 | |
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