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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10511
Species: Mus musculus
RGD Object: Gene
Symbol: Egfr
Name: epidermal growth factor receptor
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egfrdecreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of EGFR proteinPMID:23029451
Egfrmultiple interactionsEXP 6480464CTD[Arsenic Trioxide co-treated with huachansu] results in decreased expression of EGFR proteinPMID:21434348
Egfraffects response to substanceISOEGFR (Homo sapiens)6480464CTDEGFR protein affects the susceptibility to Arsenic Trioxide; EGFR protein mutant form affects the susceptibility to Arsenic TrioxidePMID:29535630 PMID:30237564
Egfrdecreases expressionISOEGFR (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of EGFR mRNA; Arsenic Trioxide results in decreased expression of EGFR proteinPMID:20435036 PMID:23029451 PMID:30237564
Egfrincreases expressionISOEGFR (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of EGFR mRNAPMID:22521957 PMID:29274334
Egfrincreases phosphorylationISOEGFR (Homo sapiens)6480464CTDArsenic Trioxide results in increased phosphorylation of EGFR proteinPMID:22532027
Egfrmultiple interactionsISOEGFR (Homo sapiens)6480464CTD4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of EGFR protein]; [Arsenic Trioxide co-treated with Pamidronate] promotes the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Arsenic Trioxide promotes the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Arsenic Trioxide promotes the reaction [EGFR protein mutant form binds to SQSTM1 protein]; Arsenic Trioxide results in decreased expression of and results in decreased phosphorylation of EGFR protein; Arsenic Trioxide results in increased phosphorylation of and results in increased activity of EGFR protein; bafilomycin A1 inhibits the reaction [Arsenic Trioxide results in decreased expression of EGFR protein]; Cycloheximide promotes the reaction [Arsenic Trioxide results in decreased expression of EGFR protein]; Erlotinib Hydrochloride inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of EGFR protein]; NCF2 mutant form inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of EGFR protein]; SQSTM1 protein affects the reaction [Arsenic Trioxide results in decreased expression of EGFR protein]; SQSTM1 protein inhibits the reaction [Arsenic Trioxide results in decreased expression of EGFR protein]PMID:15961274 PMID:22532027 PMID:23548265 PMID:30237564 PMID:32337366
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