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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10510
Species: Mus musculus
RGD Object: Gene
Symbol: Egf
Name: epidermal growth factor
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDPhenobarbital inhibits the reaction [EGF protein binds to EGFR protein]

PMID:6309801
multiple interactionsISORGD:25426480464CTDEGF protein inhibits the reaction [Phenobarbital results in increased expression of CYP2B1 mRNA], Phenobarbital inhibits the reaction [EGF protein binds to EGFR protein], Phenobarbital promotes the reaction [EGF protein results in increased phosphorylation of MAPK1 protein], Phenobarbital promotes the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]

PMID:10828207, PMID:11377398, PMID:14722249, PMID:27427493
multiple interactionsISORGD:7368326480464CTDPhenobarbital inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein], Phenobarbital inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein]

PMID:25625231, PMID:30364229
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.