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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10510
Species: Mus musculus
RGD Object: Gene
Symbol: Egf
Name: epidermal growth factor
Acc ID: CHEBI:5855
Term: ibuprofen
Definition: A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(2-methylpropyl)phenyl group.
Chemical ID: MESH:D007052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7368326480464CTDIbuprofen inhibits the reaction [EGF protein results in increased activity of MMP9 protein], Ibuprofen inhibits the reaction [EGF protein results in increased expression of MMP9 mRNA], Ibuprofen inhibits the reaction [EGF protein results in increased expression of PLAU mRNA]

PMID:16340751
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.