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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10510
Species: Mus musculus
RGD Object: Gene
Symbol: Egf
Name: epidermal growth factor
Acc ID: CHEBI:53509
Term: erlotinib hydrochloride
Definition: The hydrochloride salt of erlotinib.
Chemical ID: MESH:D000069347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:25426480464CTDErlotinib Hydrochloride inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein], Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]

PMID:27427493
multiple interactionsISORGD:7368326480464CTDErlotinib Hydrochloride inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Cisplatin]], Erlotinib Hydrochloride inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to gemcitabine]], Erlotinib Hydrochloride inhibits the reaction [EGF protein results in decreased susceptibility to Crizotinib], Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased activity of ELK1 protein], Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein], Erlotinib Hydrochloride inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein], Erlotinib Hydrochloride promotes the reaction [EGF protein binds to EGFR protein]

PMID:21613822, PMID:21787763, PMID:22553343, PMID:25625231, PMID:30364229
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.