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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10510
Species: Mus musculus
RGD Object: Gene
Symbol: Egf
Name: epidermal growth factor
Acc ID: CHEBI:3748
Term: Clivoline
Definition: A ketone that has formula C21H27NO7.
Chemical ID: MESH:C028677
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases response to substanceISORGD:7368326480464CTDEGF protein results in decreased susceptibility to clivorine

PMID:19437449
multiple interactionsISORGD:7368326480464CTDEGF protein inhibits the reaction [clivorine affects the localization of CYCS protein], EGF protein inhibits the reaction [clivorine results in decreased expression of BCL2L1 protein], EGF protein inhibits the reaction [clivorine results in increased activity of CASP9 protein], EGF protein inhibits the reaction [clivorine results in increased cleavage of CASP3 protein]

PMID:19437449
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.