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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10510
Species: Mus musculus
RGD Object: Gene
Symbol: Egf
Name: epidermal growth factor
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7368326480464CTDCadmium Chloride results in decreased expression of EGF protein

PMID:26138014
multiple interactionsISORGD:7368326480464CTDAcetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of EGF protein], EGF protein promotes the reaction [Cadmium Chloride results in increased expression of ATF4], EGF protein promotes the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]

PMID:24057571, PMID:26138014
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.