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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10510
Species: Mus musculus
RGD Object: Gene
Symbol: Egf
Name: epidermal growth factor
Acc ID: CHEBI:34202
Term: 2,2',4,4',5,5'-hexachlorobiphenyl
Definition: A hexachlorobiphenyl that has formula C12H4Cl6.
Chemical ID: MESH:C014024
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[2, 4, 4'-trichlorobiphenyl co-treated with 2, 5, 2', 5'-tetrachlorobiphenyl co-treated with 2, 4, 5, 2', 5'-pentachlorobiphenyl co-treated with 2, 2', 3', 4, 4', 5-hexachlorobiphenyl co-treated with 2, 4, 5, 2', 4', 5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of EGF mRNA

PMID:25510870
decreases expressionISORGD:7368326480464CTD2, 4, 5, 2', 4', 5'-hexachlorobiphenyl results in decreased expression of EGF mRNA

PMID:26238599
multiple interactionsISORGD:7368326480464CTD2, 4, 5, 2', 4', 5'-hexachlorobiphenyl inhibits the reaction [EGF protein binds to EGFR protein], 2, 4, 5, 2', 4', 5'-hexachlorobiphenyl inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein], 2, 4, 5, 2', 4', 5'-hexachlorobiphenyl inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein], 2, 4, 5, 2', 4', 5'-hexachlorobiphenyl inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]

PMID:29329451
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.