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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10510
Species: Mus musculus
RGD Object: Gene
Symbol: Egf
Name: epidermal growth factor
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDPTPN11 protein affects the reaction [resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]]

PMID:15849355
decreases activityISORGD:7368326480464CTDresveratrol results in decreased activity of EGF protein

PMID:16343977
decreases expressionISORGD:25426480464CTDresveratrol results in decreased expression of EGF mRNA

PMID:25905778
multiple interactionsISORGD:25426480464CTDresveratrol inhibits the reaction [EGF protein results in increased expression of MUC5AC mRNA], resveratrol inhibits the reaction [EGF protein results in increased expression of MUC5AC protein], resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein], resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased localization of GAB1 protein], resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein], resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]

PMID:15849355, PMID:16626303, PMID:22213337
multiple interactionsISORGD:7368326480464CTDEGF protein inhibits the reaction [resveratrol inhibits the reaction [TP53 protein binds to MDM2 protein]], EGF protein inhibits the reaction [resveratrol results in decreased phosphorylation of EGFR protein], EGF protein inhibits the reaction [resveratrol results in decreased phosphorylation of ERBB2 protein], EGF protein inhibits the reaction [resveratrol results in increased expression of FOS mRNA], EGF protein inhibits the reaction [resveratrol results in increased expression of JUN mRNA], EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK1 protein], EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK3 protein], EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein], gefitinib promotes the reaction [resveratrol inhibits the reaction [EGF protein results in increased expression of MMP9 mRNA]], gefitinib promotes the reaction [resveratrol inhibits the reaction [EGF protein results in increased expression of PLAU mRNA]], midostaurin inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]], PRKCA protein affects the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK1 protein]], PRKCA protein affects the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK3 protein]], PRKCA protein affects the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]], resveratrol inhibits the reaction [EGF protein results in increased expression of MMP9 mRNA], resveratrol inhibits the reaction [EGF protein results in increased expression of PLAU mRNA], resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of AKT1 protein], resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein], resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK3 protein], resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of PDPK1 protein], resveratrol promotes the reaction [EGF protein results in increased phosphorylation of EGFR protein], resveratrol promotes the reaction [gefitinib inhibits the reaction [EGF protein results in increased expression of MMP9 mRNA]], resveratrol promotes the reaction [gefitinib inhibits the reaction [EGF protein results in increased expression of PLAU mRNA]], Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol inhibits the reaction [TP53 protein binds to MDM2 protein]]], Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK1 protein]], Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK3 protein]], Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]]

PMID:14739659, PMID:15542774, PMID:16343977, PMID:20729295, PMID:23127547
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.