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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10510
Species: Mus musculus
RGD Object: Gene
Symbol: Egf
Name: epidermal growth factor
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects activityISORGD:7368326480464CTDEstradiol affects the activity of EGF protein

PMID:19395996
multiple interactionsISORGD:25426480464CTD[EGF protein co-treated with Estradiol] results in increased expression of FOS mRNA, Cycloheximide promotes the reaction [[EGF protein co-treated with Estradiol] results in increased expression of FOS mRNA], Dactinomycin inhibits the reaction [[EGF protein co-treated with Estradiol] results in increased expression of FOS mRNA], Dexamethasone promotes the reaction [[EGF protein co-treated with Estradiol] results in increased expression of FOS mRNA], Estradiol promotes the reaction [EGF protein results in increased expression of MYC mRNA], INS1 protein promotes the reaction [[EGF protein co-treated with Estradiol] results in increased expression of FOS mRNA]

PMID:12632255
multiple interactionsISORGD:7368326480464CTD[Estradiol co-treated with EGF protein] results in decreased expression of APAF1 mRNA, [Estradiol co-treated with EGF protein] results in decreased expression of BIK mRNA, [Estradiol co-treated with EGF protein] results in decreased expression of BLNK mRNA, [Estradiol co-treated with EGF protein] results in decreased expression of BMF mRNA, [Estradiol co-treated with EGF protein] results in decreased expression of BTG2 mRNA, [Estradiol co-treated with EGF protein] results in decreased expression of CASP9 mRNA, [Estradiol co-treated with EGF protein] results in decreased expression of CDKN2B mRNA, [Estradiol co-treated with EGF protein] results in decreased expression of KMT5B mRNA, [Estradiol co-treated with EGF protein] results in decreased expression of RPRM mRNA, [Estradiol co-treated with EGF protein] results in decreased expression of SGPL1 mRNA, [Estradiol co-treated with EGF protein] results in decreased expression of TGFB3 mRNA, [Estradiol co-treated with EGF protein] results in increased expression of AREG mRNA, [Estradiol co-treated with EGF protein] results in increased expression of ARTN mRNA, [Estradiol co-treated with EGF protein] results in increased expression of BMP6 mRNA, [Estradiol co-treated with EGF protein] results in increased expression of CAPN2 mRNA, [Estradiol co-treated with EGF protein] results in increased expression of CASP7 mRNA, [Estradiol co-treated with EGF protein] results in increased expression of CCNA1 mRNA, [Estradiol co-treated with EGF protein] results in increased expression of CCND1 mRNA, [Estradiol co-treated with EGF protein] results in increased expression of CDC6 mRNA, [Estradiol co-treated with EGF protein] results in increased expression of CLDN1 mRNA, [Estradiol co-treated with EGF protein] results in increased expression of CREM mRNA, [Estradiol co-treated with EGF protein] results in increased expression of CXCL12 mRNA, [Estradiol co-treated with EGF protein] results in increased expression of CXCR4 mRNA, [Estradiol co-treated with EGF protein] results in increased expression of E2F3 mRNA, [Estradiol co-treated with EGF protein] results in increased expression of E2F5 mRNA, [Estradiol co-treated with EGF protein] results in increased expression of EGR1 mRNA, [Estradiol co-treated with EGF protein] results in increased expression of ELF4 mRNA, [Estradiol co-treated with EGF protein] results in increased expression of ETV5 mRNA, [Estradiol co-treated with EGF protein] results in increased expression of FCMR mRNA, [Estradiol co-treated with EGF protein] results in increased expression of FOS mRNA, [Estradiol co-treated with EGF protein] results in increased expression of FOSL1 mRNA, [Estradiol co-treated with EGF protein] results in increased expression of GEM mRNA, [Estradiol co-treated with EGF protein] results in increased expression of GFRA2 mRNA, [Estradiol co-treated with EGF protein] results in increased expression of HBEGF mRNA, [Estradiol co-treated with EGF protein] results in increased expression of HSPB8 mRNA, [Estradiol co-treated with EGF protein] results in increased expression of IL20 mRNA, [Estradiol co-treated with EGF protein] results in increased expression of IL6R mRNA, [Estradiol co-treated with EGF protein] results in increased expression of JUN mRNA, [Estradiol co-treated with EGF protein] results in increased expression of JUNB mRNA, [Estradiol co-treated with EGF protein] results in increased expression of LIF mRNA, [Estradiol co-treated with EGF protein] results in increased expression of MAFF mRNA, [Estradiol co-treated with EGF protein] results in increased expression of MCL1 mRNA, [Estradiol co-treated with EGF protein] results in increased expression of MCM4 mRNA, [Estradiol co-treated with EGF protein] results in increased expression of MCM7 mRNA, [Estradiol co-treated with EGF protein] results in increased expression of MERTK mRNA, [Estradiol co-treated with EGF protein] results in increased expression of MITF mRNA, [Estradiol co-treated with EGF protein] results in increased expression of MYC mRNA, [Estradiol co-treated with EGF protein] results in increased expression of OSMR mRNA, [Estradiol co-treated with EGF protein] results in increased expression of PRNP mRNA, [Estradiol co-treated with EGF protein] results in increased expression of RET mRNA, [Estradiol co-treated with EGF protein] results in increased expression of SGK1 mRNA, [Estradiol co-treated with EGF protein] results in increased expression of SOX9 mRNA, [Estradiol co-treated with EGF protein] results in increased expression of TGFA mRNA, [Estradiol co-treated with EGF protein] results in increased expression of TGFBR2 mRNA, [Estradiol co-treated with EGF protein] results in increased expression of TIMP1 mRNA, [Estradiol co-treated with EGF protein] results in increased expression of VEGFA mRNA, EGF protein inhibits the reaction [[Estradiol co-treated with EGFR protein] results in increased expression of SIAH2 mRNA], EGF protein inhibits the reaction [[Estradiol co-treated with EGFR protein] results in increased expression of SIAH2 protein], EGF protein inhibits the reaction [Estradiol results in decreased expression of AKAP13 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of ARHGAP29 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of ARID5B mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of ATP1B1 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of ATP2B1 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of ATXN1 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of AXIN2 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of BHLHE40 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of BMP7 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of BMPR1B mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of CACHD1 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of CASK mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of CBLB mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of CCDC83 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of CDYL2 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of CEMIP mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of CLDN1 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of CRIM1 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of CSGALNACT1 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of CXCR4 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of DSC2 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of EFR3B mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of EGLN3 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of ELL2 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of ENPP1 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of EPAS1 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of EPHA4 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of F2RL1 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of FBXO32 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of FUT8-AS1 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of GALNT10 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of GPRC5A mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of GULP1 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of HDAC5 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of ID2 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of INPP4B mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of ITGB6 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of ITPR1 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of KLF6 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of KRT20 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of LGALS8 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of LIPH mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of LMO7 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of LXN mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of MIR21 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of MYADM mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of NFATC2 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of NFKBIZ mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of NHS mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of NME7 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of NT5E mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of NVL mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of OSBPL6 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of OXTR mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of PAPSS2 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of PAWR mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of PGM2L1 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of PLEKHH2 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of PLK2 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of PMEPA1 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of PXN mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of RASD1 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of RBMS1 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of RND1 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of RND3 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of SEMA4B mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of SFMBT2 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of SMAD3 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of STARD4 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of SYTL2 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of TBC1D8 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of TFPI mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of TGFB2 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of TM4SF1 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of TMEM45B mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of TNFRSF11B mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of UBALD2 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of VMP1 mRNA], EGF protein inhibits the reaction [Estradiol results in decreased expression of WNT3 mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of ACOT6 mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of ADRB1 mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of ARHGEF28 mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of ASCL2 mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of BCL2 mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of BLM mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of CA12 mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of CASTOR1 mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of CCM2L mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of CENPU mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of CLIC3 mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of COL12A1 mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of CPXM2 mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of DLC1 mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of DSN1 mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of FAM111B mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of FAM161A mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of HDAC11 mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of HLA-DRB1 mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of HLA-DRB6 mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of HR mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of KBTBD6 mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of KCNK5 mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of MBOAT1 mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of MCM2 mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of MCM5 mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of MICB mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of MPPED2 mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of MSMB mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of NR2F2 mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of PEX11A mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of RBL1 mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of REEP1 mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of RETREG1 mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of RHOBTB3 mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of RLN2 mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of SLC9A3R1 mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of SMOC2 mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of SOX3 mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of SYTL4 mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of TMEM229B mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of TSKU mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of TTC39A mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of WDHD1 mRNA], EGF protein inhibits the reaction [Estradiol results in increased expression of XYLT1 mRNA], EGF protein promotes the reaction [Estradiol results in decreased expression of ABCB1 mRNA], EGF protein promotes the reaction [Estradiol results in decreased expression of ADCY6 mRNA], EGF protein promotes the reaction [Estradiol results in decreased expression of ANK3 mRNA], EGF protein promotes the reaction [Estradiol results in decreased expression of ARHGEF6 mRNA], EGF protein promotes the reaction [Estradiol results in decreased expression of BCL2L1 mRNA], EGF protein promotes the reaction [Estradiol results in decreased expression of CAB39L mRNA], EGF protein promotes the reaction [Estradiol results in decreased expression of CGN mRNA], EGF protein promotes the reaction [Estradiol results in decreased expression of CLMN mRNA], EGF protein promotes the reaction [Estradiol results in decreased expression of DZIP3 mRNA], EGF protein promotes the reaction [Estradiol results in decreased expression of ELF5 mRNA], EGF protein promotes the reaction [Estradiol results in decreased expression of ERBB3 mRNA], EGF protein promotes the reaction [Estradiol results in decreased expression of FXYD3 mRNA], EGF protein promotes the reaction [Estradiol results in decreased expression of IGSF5 mRNA], EGF protein promotes the reaction [Estradiol results in decreased expression of KANSL1L mRNA], EGF protein promotes the reaction [Estradiol results in decreased expression of PACSIN1 mRNA], EGF protein promotes the reaction [Estradiol results in decreased expression of PPARA mRNA], EGF protein promotes the reaction [Estradiol results in decreased expression of SLC31A2 mRNA], EGF protein promotes the reaction [Estradiol results in decreased expression of SPATA17 mRNA], EGF protein promotes the reaction [Estradiol results in decreased expression of STAU2 mRNA], EGF protein promotes the reaction [Estradiol results in decreased expression of SYT1 mRNA], EGF protein promotes the reaction [Estradiol results in decreased expression of TMPRSS2 mRNA], EGF protein promotes the reaction [Estradiol results in decreased expression of UTRN mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of ABCE1 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of ABHD2 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of ADCY3 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of AMD1 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of ANKH mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of ARHGAP26 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of BAG2 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of CEBPG mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of CEMIP2 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of CNKSR3 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of CTSD mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of DAPK2 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of DNAJC12 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of DOK7 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of DYNLT3 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of EGR3 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of FCMR mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of FHL2 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of FRK mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of GAD1 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of GFRA2 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of HEG1 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of HIPK2 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of IFITM10 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of IL15RA mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of IL20 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of IL24 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of IRS1 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of ISG20 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of LONRF2 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of LOXL1 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of MACF1 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of MPP6 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of MREG mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of MTHFD1L mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of NAV2 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of NBPF4 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of NOLC1 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of OLFM4 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of PADI1 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of PADI3 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of PCOLCE2 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of PLAC1 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of PMAIP1 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of PNP mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of PPM1E mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of PRAG1 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of PRSS23 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of PSAT1 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of RAB31 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of RAI14 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of RUNX2 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of SEMA3B mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of SLC16A1 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of SLC1A4 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of SLC3A2 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of SNHG17 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of SOBP mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of SVIL mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of SYBU mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of SYTL5 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of TAF5L mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of THBS1 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of TIAM1 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of TMPRSS3 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of TPM1 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of TRAF3 mRNA], EGF protein promotes the reaction [Estradiol results in increased expression of TSPAN5 mRNA], EGF protein promotes the reaction [Estradiol results in increased phosphorylation of EGFR protein], Estradiol inhibits the reaction [EGF protein results in increased expression of PLAUR protein], Estradiol promotes the reaction [EGF protein results in increased phosphorylation of EGFR protein], Estradiol promotes the reaction [EGF protein results in increased phosphorylation of MAPK1 protein], Estradiol promotes the reaction [EGF protein results in increased phosphorylation of MAPK3 protein], ICI 164384 inhibits the reaction [EGF protein promotes the reaction [Estradiol results in increased expression of OLFM4 mRNA]], RTKI cpd inhibits the reaction [Estradiol promotes the reaction [EGF protein results in increased phosphorylation of EGFR protein]], Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of ARTN mRNA], Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of CCND1 mRNA], Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of CDC6 mRNA], Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of CXCL12 mRNA], Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of GFRA2 mRNA], Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of MCM4 mRNA], Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of MCM7 mRNA], Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of MERTK mRNA], Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of RET mRNA], Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of SGK1 mRNA], Tamoxifen inhibits the reaction [[Estradiol co-treated with EGF protein] results in increased expression of TGFA mRNA]

PMID:16901965, PMID:18629630, PMID:19395996, PMID:20005069, PMID:21048224, PMID:21185374, PMID:24758408
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.