GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Edn1 | multiple interactions | EXP | | 6480464 | CTD | cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [[APOE protein affects the susceptibility to Vehicle Emissions] which results in increased expression of EDN1 mRNA]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein inhibits the reaction [TNF protein results in increased expression of NOS2 protein]]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of EDN1 mRNA]; EDN1 protein affects the reaction [cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [AGT protein results in increased expression of COL1A1 protein]] | PMID:12839867 PMID:17391658 PMID:19150882 PMID:25230003 | Edn1 | decreases activity | ISO | EDN1 (Homo sapiens) | 6480464 | CTD | cyclo(Trp-Asp-Pro-Val-Leu) results in decreased activity of EDN1 protein | PMID:12906840 | Edn1 | increases secretion | ISO | EDN1 (Homo sapiens) | 6480464 | CTD | cyclo(Trp-Asp-Pro-Val-Leu) results in increased secretion of EDN1 protein | PMID:24557580 | Edn1 | multiple interactions | ISO | Edn1 (Rattus norvegicus) | 6480464 | CTD | 3,5-dibromosalicylic acid inhibits the reaction [cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein binds to EDNRA protein]]; [cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of EDN1 protein]]; cyclo(Trp-Asp-Pro-Val-Leu) affects the reaction [Ethanol affects the activity of EDN1 protein]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein binds to EDNRA protein]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased activity of TH protein]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased expression of GJA1 protein]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased expression of TH mRNA]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased metabolism of Phosphatidylinositols] | PMID:11093786 PMID:11911850 PMID:15685554 PMID:16651399 PMID:26694894 PMID:9439784 | Edn1 | multiple interactions | ISO | EDN1 (Homo sapiens) | 6480464 | CTD | [BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased phosphorylation of PTK2 protein]; [BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased phosphorylation of PXN protein]; [BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP13 protein]; [BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP3 protein]; [BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP7 protein]; [BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP9 protein]; [cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [EDN1 protein results in increased expression of BCL2 protein]; [cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [EDN1 protein results in increased localization of NFATC3 protein]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in decreased activity of Indomethacin]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP13 protein]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP3 protein]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP7 protein]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP9 protein]; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 results in decreased susceptibility to Cisplatin]; cyclo(Trp-Asp-Pro-Val-Leu) promotes the reaction [Oxygen deficiency results in increased secretion of EDN1 protein] | PMID:12875994 PMID:12906840 PMID:20369390 PMID:21656314 PMID:24557580 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |