GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Edn1 | decreases expression | ISO | EDN1 (Homo sapiens) | 6480464 | CTD | Genistein results in decreased expression of EDN1 mRNA | PMID:26865667 | Edn1 | increases methylation | ISO | Edn1 (Rattus norvegicus) | 6480464 | CTD | Genistein results in increased methylation of EDN1 gene | PMID:28505145 | Edn1 | multiple interactions | ISO | EDN1 (Homo sapiens) | 6480464 | CTD | Genistein affects the reaction [cobaltous chloride promotes the reaction [HIF1A protein binds to ARNT protein binds to EDN1 promoter]]; Genistein affects the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to ARNT protein binds to EDN1 promoter]]; Genistein inhibits the reaction [cobaltous chloride results in increased expression of EDN1 mRNA]; Genistein inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 mRNA] | PMID:10939628 | |
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