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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10473
Species: Mus musculus
RGD Object: Gene
Symbol: Nqo1
Name: NAD(P)H dehydrogenase, quinone 1
Acc ID: CHEBI:78492
Term: diallyl trisulfide
Definition: An organic trisulfide that is trisulfane in which both of the hydrogens are replaced by allyl groups. A component of the essential oil of garlic and a major component of the traditional Chinese medicine allitridium, it exhibits antifungal, antitumour and antioxidant activity
Chemical ID: MESH:C042577
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nqo1increases expressionEXP 6480464CTDdiallyl trisulfide results in increased expression of NQO1 proteinPMID:24489685 PMID:30317421
Nqo1increases expressionISONqo1 (Rattus norvegicus)6480464CTDdiallyl trisulfide results in increased expression of NQO1 mRNAPMID:20650352
Nqo1increases expressionISONQO1 (Homo sapiens)6480464CTDdiallyl trisulfide results in increased expression of NQO1 mRNA; diallyl trisulfide results in increased expression of NQO1 proteinPMID:24489685
Nqo1multiple interactionsISONQO1 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [diallyl trisulfide results in increased expression of NQO1 protein]; Dithiothreitol inhibits the reaction [diallyl trisulfide results in increased expression of NQO1 protein]; NFE2L2 mutant form inhibits the reaction [diallyl trisulfide results in increased expression of NQO1 protein]PMID:24489685
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