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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10473
Species: Mus musculus
RGD Object: Gene
Symbol: Nqo1
Name: NAD(P)H dehydrogenase, quinone 1
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nqo1decreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of NQO1 mRNAPMID:21533816
Nqo1increases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of NQO1 mRNA; Arsenic Trioxide results in increased expression of NQO1 proteinPMID:26187899 PMID:29049341
Nqo1multiple interactionsEXP 6480464CTD[Arsenic Trioxide co-treated with Grape Seed Proanthocyanidins] results in increased expression of NQO1 mRNA; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of NQO1 mRNA]; Arsenic Trioxide promotes the reaction [Lutein results in increased expression of NQO1 mRNA]; Arsenic Trioxide promotes the reaction [Lutein results in increased expression of NQO1 protein]; Arsenic Trioxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]; Buthionine Sulfoximine promotes the reaction [Arsenic Trioxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]]; Lutein promotes the reaction [Arsenic Trioxide results in increased expression of NQO1 mRNA]; Lutein promotes the reaction [Arsenic Trioxide results in increased expression of NQO1 protein]; NFE2L2 protein affects the reaction [Arsenic Trioxide results in increased expression of NQO1 mRNA]PMID:16274885 PMID:21533816 PMID:25815309 PMID:25966753 PMID:26187899 PMID:29049341
Nqo1decreases expressionISONqo1 (Rattus norvegicus)6480464CTDArsenic Trioxide results in decreased expression of NQO1 proteinPMID:32920515
Nqo1decreases expressionISONQO1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of NQO1 proteinPMID:22155346 PMID:25419056 PMID:27561292 PMID:29260515
Nqo1decreases response to substanceISONQO1 (Homo sapiens)6480464CTDNQO1 protein results in decreased susceptibility to Arsenic TrioxidePMID:20707922
Nqo1increases expressionISONQO1 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of NQO1 mRNA; Arsenic Trioxide results in increased expression of NQO1 proteinPMID:19417148 PMID:22155346 PMID:23426167 PMID:24356939 PMID:25003661 PMID:25424538 PMID:27829220 PMID:29876539 PMID:35276128
Nqo1multiple interactionsISONqo1 (Rattus norvegicus)6480464CTDcrocin inhibits the reaction [Arsenic Trioxide results in decreased expression of NQO1 protein]PMID:32920515
Nqo1multiple interactionsISONQO1 (Homo sapiens)6480464CTD[Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of NQO1 mRNA; [Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of NQO1 protein; [Resveratrol co-treated with Arsenic Trioxide] results in increased expression of NQO1 protein; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of NQO1 protein]; allicin inhibits the reaction [Arsenic Trioxide results in decreased expression of NQO1 protein]; MIR155 mRNA inhibits the reaction [Arsenic Trioxide results in decreased expression of NQO1 protein]; NFE2L2 protein promotes the reaction [Arsenic Trioxide results in increased expression of NQO1 protein]; Tretinoin inhibits the reaction [Arsenic Trioxide results in increased expression of NQO1 protein]PMID:25003661 PMID:27561292 PMID:29260515 PMID:29876539 PMID:33434570
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