GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nqo1 | increases activity | EXP | | 6480464 | CTD | Methylcholanthrene results in increased activity of NQO1 protein | PMID:15337587 | Nqo1 | increases expression | EXP | | 6480464 | CTD | Methylcholanthrene results in increased expression of NQO1 mRNA; Methylcholanthrene results in increased expression of NQO1 protein | PMID:15337587 PMID:20713471 PMID:23712962 | Nqo1 | multiple interactions | EXP | | 6480464 | CTD | Arsenic promotes the reaction [Methylcholanthrene results in increased expression of NQO1 mRNA]; Cadmium promotes the reaction [Methylcholanthrene results in increased expression of NQO1 mRNA]; Chromium inhibits the reaction [Methylcholanthrene results in increased activity of NQO1 protein]; Chromium inhibits the reaction [Methylcholanthrene results in increased expression of NQO1 mRNA] | PMID:15337587 | Nqo1 | increases activity | ISO | Nqo1 (Rattus norvegicus) | 6480464 | CTD | Methylcholanthrene results in increased activity of NQO1 protein | PMID:12206817 PMID:15302093 PMID:16906435 PMID:4005852 | Nqo1 | increases expression | ISO | Nqo1 (Rattus norvegicus) | 6480464 | CTD | Methylcholanthrene results in increased expression of NQO1 mRNA | PMID:11323195 PMID:17069994 PMID:18203689 PMID:23273579 | Nqo1 | increases expression | ISO | NQO1 (Homo sapiens) | 6480464 | CTD | Methylcholanthrene results in increased expression of NQO1 mRNA | PMID:17253728 | Nqo1 | multiple interactions | ISO | Nqo1 (Rattus norvegicus) | 6480464 | CTD | [protocatechuic acid co-treated with Methylcholanthrene] results in increased activity of NQO1 protein; Buthionine Sulfoximine promotes the reaction [Methylcholanthrene results in increased activity of NQO1 protein]; Ethoxyquin promotes the reaction [Methylcholanthrene results in increased activity of NQO1 protein]; Methylcholanthrene promotes the reaction [Buthionine Sulfoximine results in increased activity of NQO1 protein]; Methylcholanthrene promotes the reaction [Ethoxyquin results in increased activity of NQO1 protein]; Methylcholanthrene results in increased expression of and results in increased activity of NQO1 protein | PMID:15302093 PMID:16906435 PMID:18203689 | |
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