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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10473
Species: Mus musculus
RGD Object: Gene
Symbol: Nqo1
Name: NAD(P)H dehydrogenase, quinone 1
Acc ID: CHEBI:16796
Term: melatonin
Definition: A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group. It is a hormone secreted by the pineal gland in humans.
Chemical ID: MESH:D008550
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nqo1increases expressionEXP 6480464CTDMelatonin results in increased expression of NQO1 proteinPMID:25288107
Nqo1multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NQO1 mRNA]]; Acetylcysteine inhibits the reaction [Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NQO1 protein]]; Melatonin affects the reaction [manganese chloride affects the expression of NQO1 protein]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NQO1 mRNA]; Melatonin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of NQO1 protein]; Melatonin inhibits the reaction [diisodecyl phthalate inhibits the reaction [Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein]]; Melatonin inhibits the reaction [manganese chloride results in decreased expression of NQO1 protein]; Melatonin inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in decreased expression of NQO1 mRNA]]PMID:24969583 PMID:25288107 PMID:27871981 PMID:34146326 PMID:37598416
Nqo1increases expressionISONqo1 (Rattus norvegicus)6480464CTDMelatonin results in increased expression of NQO1 proteinPMID:20433640
Nqo1multiple interactionsISONqo1 (Rattus norvegicus)6480464CTD[Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of NQO1 mRNA; Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of NQO1 protein]PMID:20033131 PMID:20433640
Nqo1multiple interactionsISONQO1 (Homo sapiens)6480464CTDMelatonin inhibits the reaction [cyfluthrin results in decreased activity of NQO1 protein]; Melatonin inhibits the reaction [cyfluthrin results in increased expression of NQO1 mRNA]PMID:31330490
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