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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10473
Species: Mus musculus
RGD Object: Gene
Symbol: Nqo1
Name: NAD(P)H dehydrogenase, quinone 1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nqo1decreases expressionEXP 6480464CTDLipopolysaccharides results in decreased expression of NQO1; Lipopolysaccharides results in decreased expression of NQO1 mRNAPMID:15627257 PMID:36807594
Nqo1increases activityEXP 6480464CTDLipopolysaccharides results in increased activity of NQO1 proteinPMID:25911668
Nqo1multiple interactionsEXP 6480464CTD8-oxoberberine promotes the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of NQO1 protein]; [Lipopolysaccharides co-treated with Galactosamine] results in increased expression of NQO1 protein; Lipopolysaccharides inhibits the reaction [Benzo(a)pyrene results in increased activity of NQO1 protein]; Lipopolysaccharides inhibits the reaction [beta-Naphthoflavone results in increased expression of NQO1 mRNA]; protocatechuic acid inhibits the reaction [Lipopolysaccharides results in decreased expression of NQO1 mRNA]; Silymarin promotes the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of NQO1 protein]PMID:15627257 PMID:25911668 PMID:35691465 PMID:36807594
Nqo1decreases expressionISONQO1 (Homo sapiens)6480464CTDLipopolysaccharides results in decreased expression of NQO1 proteinPMID:36135333
Nqo1increases expressionISONqo1 (Rattus norvegicus)6480464CTDLipopolysaccharides results in increased expression of NQO1 proteinPMID:28881715
Nqo1multiple interactionsISONqo1 (Rattus norvegicus)6480464CTDNFE2L2 protein affects the reaction [Probucol promotes the reaction [Lipopolysaccharides results in increased expression of NQO1 protein]]; Probucol promotes the reaction [Lipopolysaccharides results in increased expression of NQO1 protein]PMID:28881715
Nqo1multiple interactionsISONQO1 (Homo sapiens)6480464CTD[Lipopolysaccharides co-treated with IFNG protein] promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of NQO1 mRNA]; gingerenone A inhibits the reaction [Lipopolysaccharides results in decreased expression of NQO1 protein]; NFE2L2 gene mutant form inhibits the reaction [Lipopolysaccharides results in decreased expression of NQO1 protein]PMID:30768972 PMID:36135333
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