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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10458
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp7a1
Name: cytochrome P450, family 7, subfamily a, polypeptide 1
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp7a1increases expressionEXP 6480464CTDStreptozocin results in increased expression of CYP7A1 mRNAPMID:34896238
Cyp7a1multiple interactionsEXP 6480464CTD[Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP7A1 mRNA; [Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP7A1 protein; Acrylamide inhibits the reaction [Streptozocin results in increased expression of CYP7A1 mRNA]PMID:29382564 PMID:34896238
Cyp7a1increases expressionISOCyp7a1 (Rattus norvegicus)6480464CTDStreptozocin results in increased expression of CYP7A1 mRNAPMID:10393316
Cyp7a1multiple interactionsISOCyp7a1 (Rattus norvegicus)6480464CTD[Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP7A1 mRNA; [Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP7A1 protein; Fungal Polysaccharides inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP7A1 mRNA]; Fungal Polysaccharides inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP7A1 protein]; Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP7A1 mRNA]; Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP7A1 protein]PMID:31100278
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