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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10438
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:47807
Term: sulforaphane
Definition: An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.
Chemical ID: MESH:C016766
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2decreases expressionISOCYP1A2 (Homo sapiens)6480464CTDsulforaphane results in decreased expression of CYP1A2 mRNAPMID:20442190
Cyp1a2increases expressionISOCyp1a2 (Rattus norvegicus)6480464CTDsulforaphane results in increased expression of CYP1A2 proteinPMID:15906351
Cyp1a2multiple interactionsISOCyp1a2 (Rattus norvegicus)6480464CTDsulforaphane results in decreased activity of [CYP1A2 protein co-treated with CYP1A1 protein]PMID:22664424
Cyp1a2multiple interactionsISOCYP1A2 (Homo sapiens)6480464CTDsulforaphane inhibits the reaction [1,2,5,6-dibenzanthracene results in increased activity of CYP1A2 protein]; sulforaphane inhibits the reaction [anthracene results in increased activity of CYP1A2 protein]; sulforaphane inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A2 protein]PMID:19202560 PMID:19362136
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