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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10438
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:42725
Term: 3-methyl-3H-imidazo[4,5-f]quinolin-2-amine
Definition: An imidazoquinoline that is 3H-imidazo[4,5-f]quinoline substituted by a methyl group at position 3 and an amino group at position 2.
Chemical ID: MESH:C029216
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2affects response to substanceEXP 6480464CTDCYP1A2 protein affects the susceptibility to 2-amino-3-methylimidazo(4,5-f)quinolinePMID:2023932
Cyp1a2multiple interactionsEXP 6480464CTD[CYP1A2 protein co-treated with 2-amino-3-methylimidazo(4,5-f)quinoline] results in increased mutagenesis of APRT genePMID:2023932
Cyp1a2affects metabolic processingISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein affects the metabolism of 2-amino-3-methylimidazo(4,5-f)quinolinePMID:2655891
Cyp1a2increases activityISOCyp1a2 (Rattus norvegicus)6480464CTDCYP1A2 results in increased activity of 2-amino-3-methylimidazo(4,5-f)quinolinePMID:11752233
Cyp1a2increases activityISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein results in increased activity of 2-amino-3-methylimidazo(4,5-f)quinoline; CYP1A2 results in increased activity of 2-amino-3-methylimidazo(4,5-f)quinolinePMID:15728263 PMID:2334931
Cyp1a2increases expressionISOCYP1A2 (Homo sapiens)6480464CTD2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of CYP1A2 mRNAPMID:27644595 PMID:31542801
Cyp1a2multiple interactionsISOCyp1a2 (Rattus norvegicus)6480464CTDQuercetin inhibits the reaction [CYP1A2 results in increased activity of 2-amino-3-methylimidazo(4,5-f)quinoline]PMID:11752233
Cyp1a2multiple interactionsISOCYP1A2 (Homo sapiens)6480464CTD[CYP1A2 protein co-treated with POR protein co-treated with OAT protein] results in increased susceptibility to 2-amino-3-methylimidazo(4,5-f)quinoline; CYP1A2 protein results in increased hydroxylation of and results in increased activity of 2-amino-3-methylimidazo(4,5-f)quinoline; CYP1A2 protein results in increased metabolism of and results in increased susceptibility to 2-amino-3-methylimidazo(4,5-f)quinolinePMID:10503888 PMID:14725854 PMID:28160022 PMID:9581821
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