GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp1a2 | affects response to substance | EXP | | 6480464 | CTD | CYP1A2 affects the susceptibility to Methylcholanthrene | PMID:19772856 | Cyp1a2 | increases activity | EXP | | 6480464 | CTD | Methylcholanthrene results in increased activity of CYP1A2 protein | PMID:16639589 PMID:4054433 | Cyp1a2 | increases expression | EXP | | 6480464 | CTD | Methylcholanthrene results in increased expression of CYP1A2 mRNA; Methylcholanthrene results in increased expression of CYP1A2 protein | PMID:11356909 PMID:11549291 PMID:12117779 PMID:16167840 PMID:16639589 PMID:19525444 PMID:19679878 PMID:20595379 PMID:23169610 PMID:25174530 PMID:30503582 PMID:32726451 PMID:3785172 PMID:6749129 PMID:7238523 PMID:9233375 | Cyp1a2 | increases response to substance | EXP | | 6480464 | CTD | CYP1A2 gene mutant form results in increased susceptibility to Methylcholanthrene | PMID:32726451 | Cyp1a2 | multiple interactions | EXP | | 6480464 | CTD | [Methylcholanthrene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A2 mRNA; AHR protein promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; AHR protein promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 protein]; CTNNB1 gene mutant form affects the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; CYP1A1 gene mutant form promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; CYP1A2 gene mutant form promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA] | PMID:21498875 PMID:25174530 PMID:32726451 PMID:6749129 | Cyp1a2 | increases activity | ISO | Cyp1a2 (Rattus norvegicus) | 6480464 | CTD | Methylcholanthrene results in increased activity of CYP1A2 protein | PMID:15302093 PMID:15590115 PMID:1617633 PMID:16639589 PMID:19118567 | Cyp1a2 | increases activity | ISO | CYP1A2 (Homo sapiens) | 6480464 | CTD | Methylcholanthrene results in increased activity of CYP1A2 protein | PMID:19022236 PMID:19118567 PMID:19135037 PMID:19497360 PMID:31776611 | Cyp1a2 | increases expression | ISO | Cyp1a2 (Rattus norvegicus) | 6480464 | CTD | Methylcholanthrene results in increased expression of CYP1A2 mRNA; Methylcholanthrene results in increased expression of CYP1A2 protein | PMID:10476907 PMID:10772642 PMID:11285323 PMID:11328961 PMID:11999409 PMID:15144902 PMID:16639589 PMID:19118567 PMID:19951702 PMID:20226384 PMID:20881032 PMID:23273579 PMID:28174063 PMID:30842367 PMID:7493548 PMID:8902619 PMID:9152597 | Cyp1a2 | increases expression | ISO | CYP1A2 (Homo sapiens) | 6480464 | CTD | Methylcholanthrene results in increased expression of CYP1A2 mRNA; Methylcholanthrene results in increased expression of CYP1A2 protein | PMID:12107646 PMID:15769886 PMID:16167840 PMID:19022236 PMID:19118567 PMID:19135037 PMID:20067464 PMID:20171196 PMID:23603339 PMID:27644595 PMID:27917125 PMID:28887089 PMID:33811995 PMID:8120057 PMID:9744552 PMID:9783729 | Cyp1a2 | multiple interactions | ISO | Cyp1a2 (Rattus norvegicus) | 6480464 | CTD | [[Methylcholanthrene results in increased expression of CYP1A1 protein] co-treated with [Methylcholanthrene results in increased expression of CYP1A2 protein]] results in decreased susceptibility to 3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole; [Methylcholanthrene results in increased activity of CYP1A2 protein] which results in increased oxidation of Uroporphyrinogens; lead nitrate inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A2 protein]; Methylcholanthrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; Methylcholanthrene promotes the reaction [CYP1A2 protein results in increased oxidation of Toluene]; Methylcholanthrene promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP1A2 protein]; Methylcholanthrene results in increased expression of and results in increased activity of CYP1A2 protein; protocatechuic acid inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A2 protein]; sanguinarine inhibits the reaction [Methylcholanthrene results in increased expression of and results in increased activity of CYP1A2 protein] | PMID:11999409 PMID:15302093 PMID:15946133 PMID:1617633 PMID:18486174 PMID:18493746 PMID:19788401 PMID:1994898 PMID:8902619 | Cyp1a2 | multiple interactions | ISO | CYP1A2 (Homo sapiens) | 6480464 | CTD | [Celsior co-treated with Methylcholanthrene] results in increased expression of CYP1A2 mRNA; [Dexamethasone co-treated with Mifepristone] promotes the reaction [Methylcholanthrene results in increased activity of CYP1A2 protein]; AHR protein affects the susceptibility to [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; Dehydroepiandrosterone inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; Dexamethasone inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A2 protein]; Dexamethasone promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; Methylcholanthrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; Methylcholanthrene promotes the reaction [Nicardipine results in increased expression of CYP1A2 mRNA]; Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]]; Nicardipine promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; Oxygen deficiency inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA] | PMID:15448115 PMID:18493746 PMID:19022236 PMID:20067464 PMID:20171196 PMID:23603339 PMID:33811995 | |
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