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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10438
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:34342
Term: 3-methylcholanthrene
Definition: A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.
Chemical ID: MESH:D008748
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2affects response to substanceEXP 6480464CTDCYP1A2 affects the susceptibility to MethylcholanthrenePMID:19772856
Cyp1a2increases activityEXP 6480464CTDMethylcholanthrene results in increased activity of CYP1A2 proteinPMID:16639589 PMID:4054433
Cyp1a2increases expressionEXP 6480464CTDMethylcholanthrene results in increased expression of CYP1A2 mRNA; Methylcholanthrene results in increased expression of CYP1A2 proteinPMID:11356909 PMID:11549291 PMID:12117779 PMID:16167840 PMID:16639589 PMID:19525444 PMID:19679878 PMID:20595379 PMID:23169610 PMID:25174530 PMID:30503582 PMID:32726451 PMID:3785172 PMID:6749129 PMID:7238523 PMID:9233375
Cyp1a2increases response to substanceEXP 6480464CTDCYP1A2 gene mutant form results in increased susceptibility to MethylcholanthrenePMID:32726451
Cyp1a2multiple interactionsEXP 6480464CTD[Methylcholanthrene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A2 mRNA; AHR protein promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; AHR protein promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 protein]; CTNNB1 gene mutant form affects the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; CYP1A1 gene mutant form promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; CYP1A2 gene mutant form promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]PMID:21498875 PMID:25174530 PMID:32726451 PMID:6749129
Cyp1a2increases activityISOCyp1a2 (Rattus norvegicus)6480464CTDMethylcholanthrene results in increased activity of CYP1A2 proteinPMID:15302093 PMID:15590115 PMID:1617633 PMID:16639589 PMID:19118567
Cyp1a2increases activityISOCYP1A2 (Homo sapiens)6480464CTDMethylcholanthrene results in increased activity of CYP1A2 proteinPMID:19022236 PMID:19118567 PMID:19135037 PMID:19497360 PMID:31776611
Cyp1a2increases expressionISOCyp1a2 (Rattus norvegicus)6480464CTDMethylcholanthrene results in increased expression of CYP1A2 mRNA; Methylcholanthrene results in increased expression of CYP1A2 proteinPMID:10476907 PMID:10772642 PMID:11285323 PMID:11328961 PMID:11999409 PMID:15144902 PMID:16639589 PMID:19118567 PMID:19951702 PMID:20226384 PMID:20881032 PMID:23273579 PMID:28174063 PMID:30842367 PMID:7493548 PMID:8902619 PMID:9152597
Cyp1a2increases expressionISOCYP1A2 (Homo sapiens)6480464CTDMethylcholanthrene results in increased expression of CYP1A2 mRNA; Methylcholanthrene results in increased expression of CYP1A2 proteinPMID:12107646 PMID:15769886 PMID:16167840 PMID:19022236 PMID:19118567 PMID:19135037 PMID:20067464 PMID:20171196 PMID:23603339 PMID:27644595 PMID:27917125 PMID:28887089 PMID:33811995 PMID:8120057 PMID:9744552 PMID:9783729
Cyp1a2multiple interactionsISOCyp1a2 (Rattus norvegicus)6480464CTD[[Methylcholanthrene results in increased expression of CYP1A1 protein] co-treated with [Methylcholanthrene results in increased expression of CYP1A2 protein]] results in decreased susceptibility to 3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole; [Methylcholanthrene results in increased activity of CYP1A2 protein] which results in increased oxidation of Uroporphyrinogens; lead nitrate inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A2 protein]; Methylcholanthrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; Methylcholanthrene promotes the reaction [CYP1A2 protein results in increased oxidation of Toluene]; Methylcholanthrene promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP1A2 protein]; Methylcholanthrene results in increased expression of and results in increased activity of CYP1A2 protein; protocatechuic acid inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A2 protein]; sanguinarine inhibits the reaction [Methylcholanthrene results in increased expression of and results in increased activity of CYP1A2 protein]PMID:11999409 PMID:15302093 PMID:15946133 PMID:1617633 PMID:18486174 PMID:18493746 PMID:19788401 PMID:1994898 PMID:8902619
Cyp1a2multiple interactionsISOCYP1A2 (Homo sapiens)6480464CTD[Celsior co-treated with Methylcholanthrene] results in increased expression of CYP1A2 mRNA; [Dexamethasone co-treated with Mifepristone] promotes the reaction [Methylcholanthrene results in increased activity of CYP1A2 protein]; AHR protein affects the susceptibility to [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; Dehydroepiandrosterone inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; Dexamethasone inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A2 protein]; Dexamethasone promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; Methylcholanthrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; Methylcholanthrene promotes the reaction [Nicardipine results in increased expression of CYP1A2 mRNA]; Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]]; Nicardipine promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; Oxygen deficiency inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]PMID:15448115 PMID:18493746 PMID:19022236 PMID:20067464 PMID:20171196 PMID:23603339 PMID:33811995
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