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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10438
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:34206
Term: 2,2',5,5'-tetrachlorobiphenyl
Definition: A tetrachlorobiphenyl that is biphenyl in which the hydrogens at the 2 and 5 position of each benzene ring are replaced by chlorines.
Chemical ID: MESH:C009407
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2affects response to substanceISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein affects the susceptibility to 2,5,2',5'-tetrachlorobiphenylPMID:27913846
Cyp1a2increases expressionISOCYP1A2 (Homo sapiens)6480464CTD2,5,2',5'-tetrachlorobiphenyl results in increased expression of CYP1A2 mRNAPMID:21703328
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