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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10436
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:35861
Term: dibenzo[a,l]pyrene
Definition: An ortho- and peri-fused polycyclic arene that has formula C24H14.
Chemical ID: MESH:C041517
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1decreases expressionEXP 6480464CTDdibenzo(a,l)pyrene results in decreased expression of CYP1A1 mRNAPMID:23274566
Cyp1a1increases activityEXP 6480464CTDCYP1A1 protein results in increased activity of dibenzo(a,l)pyrenePMID:15606143
Cyp1a1increases expressionEXP 6480464CTDdibenzo(a,l)pyrene results in increased expression of CYP1A1 mRNA; dibenzo(a,l)pyrene results in increased expression of CYP1A1 proteinPMID:12117779 PMID:17060372
Cyp1a1multiple interactionsEXP 6480464CTDdibenzo(a,l)pyrene promotes the reaction [Dust results in increased expression of CYP1A1 protein]; Dust promotes the reaction [dibenzo(a,l)pyrene results in increased expression of CYP1A1 protein]PMID:17060372
Cyp1a1affects expressionISOCyp1a1 (Rattus norvegicus)6480464CTDdibenzo(a,l)pyrene affects the expression of CYP1A1 mRNAPMID:27099206
Cyp1a1decreases expressionISOCYP1A1 (Homo sapiens)6480464CTDdibenzo(a,l)pyrene results in decreased expression of CYP1A1 mRNAPMID:31255691 PMID:32890658
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTDdibenzo(a,l)pyrene results in increased expression of CYP1A1 mRNA; dibenzo(a,l)pyrene results in increased expression of CYP1A1 proteinPMID:15566942 PMID:16269432 PMID:25398514
Cyp1a1multiple interactionsISOCyp1a1 (Rattus norvegicus)6480464CTD1,2,5,6-dibenzanthracene promotes the reaction [dibenzo(a,l)pyrene results in increased expression of CYP1A1 mRNA]; dibenzo(a,l)pyrene affects the reaction [Benzo(a)pyrene affects the expression of CYP1A1 mRNA]; dibenzo(a,l)pyrene promotes the reaction [1,2,5,6-dibenzanthracene results in increased expression of CYP1A1 mRNA]; dibenzo(a,l)pyrene promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]PMID:18711122 PMID:27099206
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTD[phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of CYP1A1 mRNA; TP53 protein affects the reaction [dibenzo(a,l)pyrene results in increased expression of CYP1A1 protein]PMID:15566942 PMID:25398514
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