GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp1a1 | affects expression | EXP | | 6480464 | CTD | o,p'-DDT affects the expression of CYP1A1 mRNA | PMID:18925944 | Cyp1a1 | increases expression | EXP | | 6480464 | CTD | o,p'-DDT results in increased expression of CYP1A1 mRNA | PMID:28263910 | Cyp1a1 | multiple interactions | EXP | | 6480464 | CTD | o,p'-DDT inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; o,p'-DDT inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; o,p'-DDT promotes the reaction [AHR protein binds to CYP1A1 promoter] | PMID:12176094 | | ||||||||||||||||||||||
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