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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10436
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1decreases expressionEXP 6480464CTDDiethylhexyl Phthalate results in decreased expression of CYP1A1 mRNAPMID:19245819
Cyp1a1increases expressionEXP 6480464CTDDiethylhexyl Phthalate results in increased expression of CYP1A1 mRNA; Diethylhexyl Phthalate results in increased expression of CYP1A1 proteinPMID:36403809 PMID:36781136
Cyp1a1multiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin co-treated with bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate] results in increased expression of CYP1A1 mRNA; Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of CYP1A1 mRNA]; Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of CYP1A1 protein]PMID:23756648 PMID:36403809
Cyp1a1affects response to substanceISOCYP1A1 (Homo sapiens)6480464CTDCYP1A1 protein affects the susceptibility to Diethylhexyl PhthalatePMID:8242868
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTDDiethylhexyl Phthalate metabolite results in increased expression of CYP1A1; Diethylhexyl Phthalate results in increased expression of CYP1A1 proteinPMID:16954067 PMID:34801851
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