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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10425
Species: Mus musculus
RGD Object: Gene
Symbol: Cycs
Name: cytochrome c, somatic
Acc ID: CHEBI:90695
Term: anthra[1,9-cd]pyrazol-6(2H)-one
Definition: A member of the class of anthrapyrazoles that is anthra[1,9-cd]pyrazole substituted at position 6 by an oxo group. An inhibitor of c-Jun N-terminal kinase.
Chemical ID: MESH:C432165
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cycsmultiple interactionsEXP 6480464CTDpyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal affects the localization of CYCS protein]PMID:16322078
Cycsmultiple interactionsISOCYCS (Homo sapiens)6480464CTDpyrazolanthrone inhibits the reaction [4-vinyl-2,6-dimethoxyphenol results in increased expression of CYCS protein]; pyrazolanthrone inhibits the reaction [surfactin peptide affects the localization of CYCS protein]; pyrazolanthrone promotes the reaction [Arsenic Trioxide affects the localization of CYCS protein]PMID:16972261 PMID:19954742 PMID:30653946
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