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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10368
Species: Mus musculus
RGD Object: Gene
Symbol: Abcc2
Name: ATP-binding cassette, sub-family member 2
Acc ID: CHEBI:76290
Term: PhIP
Definition: An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
Chemical ID: MESH:C049584
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc2affects metabolic processingEXP 6480464CTDABCC2 protein affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridinePMID:30701287
Abcc2affects transportEXP 6480464CTDABCC2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridinePMID:16611851
Abcc2multiple interactionsEXP 6480464CTD[ABCC2 protein affects the metabolism of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine; ABCC2 protein affects the susceptibility to [Dextran Sulfate co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]PMID:30701287
Abcc2affects transportISOAbcc2 (Rattus norvegicus)6480464CTDABCC2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridinePMID:15057744
Abcc2increases expressionISOABCC2 (Homo sapiens)6480464CTD2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ABCC2 mRNAPMID:18680760
Abcc2increases transportISOAbcc2 (Rattus norvegicus)6480464CTDABCC2 protein results in increased transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridinePMID:11306678
Abcc2increases transportISOABCC2 (Homo sapiens)6480464CTDABCC2 protein results in increased transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridinePMID:11306678
Abcc2multiple interactionsISOABCC2 (Homo sapiens)6480464CTD[Cyclosporine results in decreased activity of ABCC2 protein] which affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridinePMID:16356829
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