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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10368
Species: Mus musculus
RGD Object: Gene
Symbol: Abcc2
Name: ATP-binding cassette, sub-family member 2
Acc ID: CHEBI:44185
Term: methotrexate
Definition: A pteridine that has formula C20H22N8O5.
Chemical ID: MESH:D008727
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc2affects exportEXP 6480464CTDABCC2 protein affects the export of MethotrexatePMID:22095822
Abcc2affects transportEXP 6480464CTDABCC2 protein affects the transport of MethotrexatePMID:16611851
Abcc2multiple interactionsEXP 6480464CTDABCC2 protein affects the reaction [Fosinopril affects the export of Methotrexate]PMID:22095822
Abcc2affects response to substanceISOABCC2 (Homo sapiens)6480464CTDABCC2 gene SNP affects the susceptibility to MethotrexatePMID:18381794 PMID:23222202
Abcc2affects transportISOABCC2 (Homo sapiens)6480464CTDABCC2 protein affects the transport of MethotrexatePMID:11500505
Abcc2decreases expressionISOAbcc2 (Rattus norvegicus)6480464CTDMethotrexate results in decreased expression of ABCC2 mRNA; Methotrexate results in decreased expression of ABCC2 proteinPMID:16925582
Abcc2decreases response to substanceISOABCC2 (Homo sapiens)6480464CTDABCC2 protein results in decreased susceptibility to MethotrexatePMID:19394316 PMID:22095822
Abcc2increases exportISOAbcc2 (Rattus norvegicus)6480464CTDABCC2 protein results in increased export of MethotrexatePMID:12608533
Abcc2increases expressionISOABCC2 (Homo sapiens)6480464CTDMethotrexate results in increased expression of ABCC2 mRNAPMID:23897011
Abcc2increases importISOAbcc2 (Rattus norvegicus)6480464CTDABCC2 protein results in increased import of MethotrexatePMID:19067394
Abcc2increases response to substanceISOABCC2 (Homo sapiens)6480464CTDABCC2 polymorphism results in increased susceptibility to Methotrexate; ABCC2 protein mutant form results in increased susceptibility to MethotrexatePMID:15864128 PMID:21887680
Abcc2multiple interactionsISOAbcc2 (Rattus norvegicus)6480464CTDLeucovorin inhibits the reaction [Methotrexate results in decreased expression of ABCC2 protein]PMID:16925582
Abcc2multiple interactionsISOABCC2 (Homo sapiens)6480464CTDABCC2 gene polymorphism affects the susceptibility to and affects the metabolism of Methotrexate; ABCC2 protein affects the export of and results in decreased susceptibility to Methotrexate; Methotrexate inhibits the reaction [ABCC2 protein results in increased export of Fosinopril]PMID:15864128 PMID:22095822 PMID:25007187
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