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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10368
Species: Mus musculus
RGD Object: Gene
Symbol: Abcc2
Name: ATP-binding cassette, sub-family member 2
Acc ID: CHEBI:16325
Term: lithocholic acid
Definition: A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.
Chemical ID: MESH:D008095
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc2affects localizationEXP 6480464CTDLithocholic Acid affects the localization of ABCC2 proteinPMID:16436656
Abcc2increases expressionEXP 6480464CTDLithocholic Acid results in increased expression of ABCC2 mRNA; Lithocholic Acid results in increased expression of ABCC2 proteinPMID:20977460 PMID:25582706
Abcc2multiple interactionsEXP 6480464CTD[Lithocholic Acid co-treated with oltipraz] results in increased expression of ABCC2 protein; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC2 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC2 protein]PMID:18032408 PMID:20977460
Abcc2increases expressionISOAbcc2 (Rattus norvegicus)6480464CTDLithocholic Acid results in increased expression of ABCC2 mRNAPMID:20888898
Abcc2increases expressionISOABCC2 (Homo sapiens)6480464CTDLithocholic Acid results in increased expression of ABCC2 mRNAPMID:20888898
Abcc2multiple interactionsISOAbcc2 (Rattus norvegicus)6480464CTD[Lithocholic Acid binds to and results in increased activity of NR1I2 protein] which results in increased expression of ABCC2 mRNAPMID:21311750
Abcc2multiple interactionsISOABCC2 (Homo sapiens)6480464CTD[Cyclosporine results in decreased activity of ABCC2 protein] which results in increased abundance of Lithocholic Acid; [Lithocholic Acid results in increased activity of NR1I2 protein] which results in increased expression of ABCC2 mRNAPMID:14570758 PMID:26198044
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