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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10357
Species: Mus musculus
RGD Object: Gene
Symbol: Chrna7
Name: cholinergic receptor, nicotinic, alpha polypeptide 7
Acc ID: CHEBI:4803
Term: epibatidine
Definition: An alkaloid that has formula C11H13ClN2.
Chemical ID: MESH:C082748
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrna7affects activityISOCHRNA7 (Homo sapiens)6480464CTDepibatidine affects the activity of CHRNA7 proteinPMID:29248576
Chrna7affects bindingISOCHRNA7 (Homo sapiens)6480464CTDepibatidine binds to CHRNA7 proteinPMID:21703337
Chrna7multiple interactionsISOChrna7 (Rattus norvegicus)6480464CTDepibatidine inhibits the reaction [iodo-alpha-bungarotoxin binds to CHRNA7 protein]PMID:19448648
Chrna7multiple interactionsISOCHRNA7 (Homo sapiens)6480464CTD1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea promotes the reaction [epibatidine affects the activity of CHRNA7 protein]; Bungarotoxins inhibits the reaction [epibatidine binds to CHRNA7 protein]; Carbachol inhibits the reaction [epibatidine binds to CHRNA7 protein]; methyllycaconitine inhibits the reaction [epibatidine binds to CHRNA7 protein]; PNU-282987 inhibits the reaction [epibatidine binds to CHRNA7 protein]; SAD-128 analog inhibits the reaction [epibatidine binds to CHRNA7 protein]PMID:21703337 PMID:29248576
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