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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10355
Species: Mus musculus
RGD Object: Gene
Symbol: Chrna4
Name: cholinergic receptor, nicotinic, alpha polypeptide 4
Acc ID: CHEBI:15354
Term: choline
Definition: A choline that is the parent compound of the cholines class, consisting of ethanolamine having three methyl substituents attached to the amino function.
Chemical ID: MESH:D002794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrna4multiple interactionsEXP 6480464CTDCholine inhibits the reaction [Sodium Fluoride results in decreased expression of CHRNA4 mRNA]PMID:36286330
Chrna4affects activityISOChrna4 (Rattus norvegicus)6480464CTDCholine affects the activity of CHRNA4 proteinPMID:19047205
Chrna4multiple interactionsISOCHRNA4 (Homo sapiens)6480464CTDCholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]; Choline inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]PMID:14645658
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