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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10322
Species: Mus musculus
RGD Object: Gene
Symbol: Cdkn2a
Name: cyclin dependent kinase inhibitor 2A
Acc ID: CHEBI:73755
Term: 1,2-dimethylhydrazine
Definition: A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice.
Chemical ID: MESH:D019813
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn2aincreases expressionEXP 6480464CTD1,2-Dimethylhydrazine results in increased expression of CDKN2A mRNA; 1,2-Dimethylhydrazine results in increased expression of CDKN2A proteinPMID:26388957
Cdkn2amultiple interactionsEXP 6480464CTD[NFE2L2 protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of CDKN2A mRNA; sulforaphane inhibits the reaction [[NFE2L2 protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of CDKN2A mRNA]; sulforaphane promotes the reaction [1,2-Dimethylhydrazine results in increased expression of CDKN2A mRNA]; sulforaphane promotes the reaction [1,2-Dimethylhydrazine results in increased expression of CDKN2A protein]PMID:26388957
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