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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10298
Species: Mus musculus
RGD Object: Gene
Symbol: Cck
Name: cholecystokinin
Acc ID: CHEBI:94686
Term: orlistat
Definition: A carboxylic ester resulting from the formal condensation of the carboxy group of N-formyl-L-leucine with the hydroxy group of (3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one. A pancreatic lipase inhibitor, it is used as an anti-obesity drug.
Chemical ID: MESH:C055122
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cckdecreases secretionISOCCK (Homo sapiens)6480464CTDorlistat results in decreased secretion of CCK proteinPMID:18647814
Cckmultiple interactionsISOCCK (Homo sapiens)6480464CTD[[orlistat results in decreased abundance of Fatty Acids, Nonesterified] which results in decreased secretion of CCK protein] which results in decreased secretion of PNLIP protein; orlistat inhibits the reaction [Fats results in increased secretion of CCK protein]; orlistat inhibits the reaction [Olive Oil results in increased secretion of CCK protein]PMID:11408251 PMID:18303078
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