GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp3 | increases activity | EXP | | 6480464 | CTD | chromium hexavalent ion results in increased activity of CASP3 protein | PMID:24374135 | Casp3 | affects cleavage | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | chromium hexavalent ion affects the cleavage of CASP3 protein | PMID:15831465 | Casp3 | increases activity | ISO | Casp3 (Rattus norvegicus) | 6480464 | CTD | chromium hexavalent ion results in increased activity of CASP3 protein | PMID:19459161 | Casp3 | increases activity | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | chromium hexavalent ion results in increased activity of CASP3 protein | PMID:15966574 PMID:16166740 PMID:22710416 PMID:24732427 PMID:30236763 PMID:31433169 | Casp3 | increases cleavage | ISO | Casp3 (Rattus norvegicus) | 6480464 | CTD | chromium hexavalent ion results in increased cleavage of CASP3 protein | PMID:24530425 | Casp3 | increases cleavage | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | chromium hexavalent ion results in increased cleavage of CASP3 protein | PMID:17301063 PMID:29069462 | Casp3 | multiple interactions | ISO | Casp3 (Rattus norvegicus) | 6480464 | CTD | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [[Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in increased cleavage of CASP3 protein]; [Potassium Dichromate results in increased abundance of chromium hexavalent ion] promotes the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in increased cleavage of CASP3 protein]; [Potassium Dichromate results in increased abundance of chromium hexavalent ion] which results in increased cleavage of CASP3 protein; benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein] | PMID:19459161 PMID:35307491 PMID:36849043 | Casp3 | multiple interactions | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | [chromium hexavalent ion co-treated with Antimycin A] results in increased activity of CASP3 protein; [chromium hexavalent ion co-treated with Rotenone] results in increased activity of CASP3 protein; [Glutamic Acid co-treated with malic acid co-treated with Ubiquinone] inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; [Glutamic Acid co-treated with malic acid] inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; [SEMA3A protein co-treated with chromium hexavalent ion] results in increased activity of CASP3 protein; Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; Adenosine Triphosphate inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; Ascorbic Acid inhibits the reaction [[chromium hexavalent ion co-treated with Antimycin A] results in increased activity of CASP3 protein]; Ascorbic Acid inhibits the reaction [[chromium hexavalent ion co-treated with Rotenone] results in increased activity of CASP3 protein]; Ascorbic Acid inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; Ascorbic Acid promotes the reaction [chromium hexavalent ion results in increased cleavage of CASP3 protein]; benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [TP53 protein affects the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]]; chromium hexavalent ion results in increased cleavage of and results in increased activity of CASP3 protein; MLH1 protein affects the reaction [chromium hexavalent ion affects the activity of CASP3 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine affects the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; Sirolimus inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; TP53 protein affects the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; Ubiquinone inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; Zinc affects the reaction [chromium hexavalent ion results in increased activity of CASP3 protein] | PMID:15831465 PMID:15966574 PMID:16166740 PMID:17301063 PMID:22886373 PMID:24732427 PMID:30236763 | | ||||||||||||||||||||||
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