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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10289
Species: Mus musculus
RGD Object: Gene
Symbol: Casp3
Name: caspase 3
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp3affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of CASP3 mRNAPMID:21570461
Casp3decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of CASP3 mRNAPMID:15034205
Casp3increases activityEXP 6480464CTDTetrachlorodibenzodioxin results in increased activity of CASP3 proteinPMID:12962974 PMID:16080534 PMID:21846477 PMID:36782369
Casp3increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of CASP3 mRNA; Tetrachlorodibenzodioxin results in increased expression of CASP3 proteinPMID:12167310 PMID:33823233
Casp3multiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin co-treated with AHR protein] results in increased activity of CASP3 protein; AHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CASP3 mRNA]; IGFBP6 protein promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CASP3 protein]; NFE2L2 gene mutant form promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CASP3 protein]; Tetrachlorodibenzodioxin inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]; Tetrachlorodibenzodioxin results in increased cleavage of and affects the activity of CASP3 protein; Tetrachlorodibenzodioxin results in increased cleavage of and results in increased activity of CASP3 proteinPMID:12878042 PMID:12962974 PMID:14718643 PMID:15034205 PMID:15664267 PMID:21534955 PMID:21846477
Casp3affects expressionISOCASP3 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin affects the expression of CASP3 mRNAPMID:22574217
Casp3decreases expressionISOCasp3 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of CASP3 mRNAPMID:18796159 PMID:21215274 PMID:34747641
Casp3decreases expressionISOCASP3 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of CASP3 mRNAPMID:23152189
Casp3increases activityISOCasp3 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased activity of CASP3 proteinPMID:20302886
Casp3increases cleavageISOCasp3 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased cleavage of CASP3 proteinPMID:24932542
Casp3increases expressionISOCasp3 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of CASP3 mRNAPMID:19520675
Casp3multiple interactionsISOCasp3 (Rattus norvegicus)6480464CTDAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of CASP3 mRNA]; EIF2S1 mutant form promotes the reaction [Tetrachlorodibenzodioxin results in increased cleavage of CASP3 protein]; salubrinal inhibits the reaction [Tetrachlorodibenzodioxin results in increased cleavage of CASP3 protein]; Tetrachlorodibenzodioxin promotes the reaction [Camptothecin results in increased cleavage of CASP3 protein]PMID:21215274 PMID:24932542 PMID:25843524
Casp3multiple interactionsISOCASP3 (Homo sapiens)6480464CTDfostriecin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of CASP3 protein]]; Okadaic Acid inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of CASP3 protein]]; Tetrachlorodibenzodioxin affects the reaction [dibenzo(a,l)pyrene results in increased cleavage of CASP3 protein]; Tetrachlorodibenzodioxin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of CASP3 protein]; Tetrachlorodibenzodioxin inhibits the reaction [Etoposide results in increased activity of CASP3 protein]PMID:20299546 PMID:24954032
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